- Title
- Norfloxacin and metronidazole topical formulations for effective treatment of bacterial infections and burn wounds
- Creator
- Dua, Kamal; Malipeddi, Venkata Ramana; Madan, Jyotsna; Gupta, Gaurav; Chakravarthi, Srikumar; Awasthi, Rajendra; Kikuchi, Irene Satiko; De Pinto, Terezinha De Jesus Andreoli
- Relation
- Interventional Medicine and Applied Science Vol. 8, Issue 2, p. 68-76
- Publisher Link
- http://dx.doi.org/10.1556/1646.8.2016.2.4
- Publisher
- Akademiai Kiado
- Resource Type
- journal article
- Date
- 2016
- Description
- Introduction: Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with Curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems. Aims and methods: Keeping these facts in consideration, we have made an another attempt to prepare semisolid formulations containing 1% w/w of norfloxacin and metronidazole with different bases like Carbopol, polyethylene glycol, and hydroxypropylmethyl cellulose for effective treatment of bacterial infections and burn wounds. The prepared formulations were evaluated for physicochemical parameters, in vitro drug release, antimicrobial activity, and burn wound healing properties. Results: The prepared formulations were compared with Silver Sulfadiazine cream 1%, USP. Antimicrobial activity of norfloxacin semisolid formulations was found to be equally effective against both aerobic and anaerobic bacteria in comparison to a marketed formulation of Silver Sulfadiazine 1% cream, USP. Based on the burn wound healing property, the prepared norfloxacin semisolid formulation was found to be in good agreement with marketed Silver Sulfadiazine 1% cream, USP. Conclusions: These findings suggest formulations containing norfloxacin and metronidazole may also prove as an effective alternative for existing remedies in the treatment of bacterial infections and burn wounds.
- Subject
- transdermal; ointments; norfloxacin; gels; infection; burns
- Identifier
- http://hdl.handle.net/1959.13/1345202
- Identifier
- uon:29589
- Identifier
- ISSN:2061-1617
- Rights
- © 2016 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited.
- Language
- eng
- Full Text
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